官网链接
折扣/货期| 货号：96-239 | 规格：0.2 mg | 目录价：￥11547.9 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DKK 3 Recombinant Protein
别名:
DKK3, REIC, RIG
实验应用:
WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
纯度:
>95% as determined by SDS-PAGE.
Accession #:
NP_001018067.1
您可能感兴趣的产品
Influenza B Strain B/Hong Kong 5/72 Antigen
货号：11-576
TMIGD2 Recombinant Protein
货号：RF16120-01
TIM3 Recombinant Protein
货号：RF16100-01
B7-H3 Recombinant Protein
货号：RF16090-01
LAG-3 Recombinant Protein
货号：RF16080-01
B7-H5 Recombinant Protein
货号：RF16070-01
LIGHT Recombinant Protein
货号：RF16060-01
B7-1 Recombinant Protein
货号：RF16040-01
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询