DMPO Antibody: RPE-单抗-深圳欣博盛生物科技有限公司

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DMPO Antibody: RPE

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-189D-RPE

规格：100 µg

目录价：￥5027.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

DMPO Antibody: RPE

别名:

5,5-dimethyl-2-(8-octanoic acid)-1-pyrroline N oxide Antibody, DMPO nitrone adduct Antibody, 55 dimethyl 1 pyrroline N oxide nitrone adduct antibody

产品描述:

Mouse Anti-DMPO Monoclonal IgG1

反应种属:

Species Independent

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP | ELISA | AM

靶标/特异性:

Recognizes DMPO, DMPO-octanoic acid, DMPO-protein adducts and DMPO-DNA adducts. Does not cross react with non-adducted proteins or DNA.

同种型:

IgG1

推荐稀释度:

WB (1:1000), ICC/IF (1:100), ELISA (1:100), IP (25µg); optimal dilutions for assays should be determined by the user.

免疫原:

5,5-dimethyl-2-(8-octanoic acid)-1-pyrrolone-N-oxide conjugated to Ovalbumin

克隆性:

Monoclonal

克隆号:

N1664A

纯化方式:

Protein G Purified

偶联:

RPE

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states (1). The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems (2-6). Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals (1). DMPO adducts can be generated with protein and DNA radicals (7).