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折扣/货期| 货号：CDX-D0257-M010 | 规格：10 mg | 目录价：￥714 |
| 货号：CDX-D0257-M050 | 规格：50 mg | 目录价：￥1680 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Doxorubicin hydrochloride
别名:
DOX; Hydroxydaunorubicin; Adriamycin; NSC 123127
产品描述:
Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species (ROS) in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake. Doxorubicin can also induce the opening of mitochondrial permeability transition pore, resulting in the loss of mitochondrial membrane potential, thus explaining DOX-mediated apoptosis in cardiomyocytes. Doxorubicin is a substrate of MRP1. Doxorubicin shows antimalarial activity and has been shown to inhibit parasite growth. Doxorubicin is used in the treatment of non-Hodgkin′s lymphoma and other cancers. Doxorubicin is naturally fluorescent with lambdaex at 480nm and lambdaem at 600nm. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
579.98
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98 (HPLC)
CAS号:
25316-40-9
分子式:
C27H29NO11 . HCl
溶解度:
Soluble in DMSO (20mg/ml) or water (20mg/ml). Slightly soluble in methanol.
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