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折扣/货期| 货号：95-119 | 规格：0.05 mg | 目录价：￥4226.625 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DR6 Cytoplasmic Domain Recombinant Protein
别名:
DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
实验应用:
ELISA,WB
表达系统:
E. coli
保存温度:
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
1X PBS containing 10% glycerol
产地:
美国
生产商:
Prosci
功能与背景:
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3). The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
纯度:
~95%
Accession #:
NP_055267
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