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折扣/货期| 货号：GTX10415 | 规格：100μl | 目录价：￥5400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EGFR antibody [F4]
别名:
epidermal growth factor receptor , ERBB , ERBB1 , HER1 , NISBD2 , PIG61 , mENA
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, IHC-Fr, IHC-P, IP, WB
靶标/特异性:
This antibody recognizes specifically an intracellular domain of the EGF receptor.
同种型:
IgG1
免疫原:
synthetically produced residues 985-996 of the human EGF receptor.
克隆性:
Monoclonal
克隆号:
F4
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
134
产品形式:
Liquid
存储溶液:
Ascites, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
The receptor for Epidermal Growth Factor is an integral cell membrane protein of 170 kD, which spans the membranes of a wide range of normal and malignant epithelial cells. It is a tyrosine-specific protein kinase with the capacity to phosphorylate tyrosine residues located near its carboxy-terminus. EGF-R has anextracellular region which binds EGF and consequently mediates the initial response of cells to EGF and an intra-cellular region which posseses the tyrosine kinase activity. As a result of EGF binding to its specific receptor, there is increased DNA synthesis as well as other events including cell proliferation, differentiation and repair of damaged epithelial tissue. The EGF-R has a half-life of approximately 10 hours in human fibroblasts, but in the presence of EGF this value is reduced to about 1 hour. A close similarity has been found between the sequence of the v-erb-B oncogene and the cytoplasmic and transmembrane part of the EGF-R (truncatedEGF-R). It is hypothesized that an inappropriate activation of the human erb-B gene either by truncation or overexpression plays a role in the development of the malignancy. This hypothesis is supported by studies, which have shown an increased number of EGF-R in various malignant tumors. High levels of EGF-R have been identified in sarcomas, gliomas, gynecological, breast, bladder, and lung tumors.
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