官网链接
折扣/货期| 货号：GTX10414 | 规格：100μl | 目录价：￥7900 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
EGFR antibody [29.1]
别名:
epidermal growth factor receptor , ERBB , ERBB1 , HER1 , NISBD2 , PIG61 , mENA
反应种属:
Dog, Human, Mouse, Pig, Rat
宿主来源:
Mouse
实验应用:
ELISA, IHC, IP, WB
靶标/特异性:
Localizes blood type A-related determinants on various glycoproteins and glycolipids in addition to specific EGF receptor determinants (only observed in human tissue). Binds an external carbohydrate on the receptor and does not block EGF binding.
同种型:
IgG1
免疫原:
human carcinoma cell line A431, which expresses high levels of EGF receptors.
克隆性:
Monoclonal
克隆号:
29.1
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
The receptor for Epidermal Growth Factor is an integral cell membrane protein of 170 kDa, which spans the membranes of a wide range of normal and malignant epithelial cells. It is a tyrosine-specific protein kinase with the capacity to phosphorylate tyrosine residues located near its carboxy-terminus. EGF-R has anextracellular region which binds EGF and consequently mediates the initial response of cells to EGF and an intra- cellular region which posseses the tyrosine kinase activity. As a result of EGF binding to its specific receptor, there is increased DNA synthesis as well as other events such as cell proliferation, differentiationand repair of damaged epithelial tissue. The EGF-R has a half-life of approximately 10 hours in human fibroblasts, but in the presence of EGF this value is reduced to about 1 hour. A close similarity has been found between the sequence of the v-erb-B oncogene and the cytoplasmic and transmembrane part of the EGF-R (truncated EGF-R). It is hypothesized that an inappropriate activation of the human erb-B gene either by truncation or overexpression plays a role in the development of the malignancy. This hypothesis is supported by studies which have shown an increased number of EGF-R in various malignant tumors. High levels of EGF-R have been identified in sarcomas, gliomas, gynecological, breast, bladder and lungtumors.
您可能感兴趣的产品
4-hydroxy Nonenal Monoclonal Antibody (HNEJ-1/Clone IG10) - HRP Conjugated
货号：45025
ICAM4 antibody [HL5612]
货号：GTX646294
14-3-3 epsilon antibody [HL5606]
货号：GTX646288
Ras (Q61H mutant) antibody [HL5601]
货号：GTX646283
ALDH1L1 antibody [HL5536]
货号：GTX646210
AAV13 Capsid protein VP1 + VP2 + VP3 antibody [HL5535]
货号：GTX646198
ESAM antibody [HL5518]
货号：GTX646181
CD79a antibody [HL5516]
货号：GTX646179
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询