GE23077 A1/B1-其他小分子化合物-深圳欣博盛生物科技有限公司

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GE23077 A1/B1

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0305-M001	规格：1 mg	目录价：￥1080
货号：AG-CN2-0305-M005	规格：5 mg	目录价：￥3840
货号：AG-CN2-0305-M025	规格：25 mg	目录价：￥11520

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GE23077 A1/B1

别名:

Antibiotic GE23077A1/Antibiotic GE23077B1 Mixture

产品描述:

Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase (RNAP). Inhibits Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic (wheat germ) RNAP II (IC50 values >100µM). Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of membrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase (RNAP) active-center 'i' and 'i+1' nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation. Tool for mechanistic studies on bacterial RNAP and for potential anti-infective drug discovery.

宿主来源:

Isolated from Actinomadura sp.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

805.8 [A1]803.8 [B1]

产品形式:

solid

产地:

瑞士