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折扣/货期| 货号：CDX-G0063-M010 | 规格：10 mg | 目录价：￥630 |
| 货号：CDX-G0063-M050 | 规格：50 mg | 目录价：￥2128 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Gemcitabine hydrochloride
别名:
2'-Deoxy-2',2'-difluorocytidine; dFdC; Gemzar (Lilly); LY-188011; dFdC; dFdCyd; NSC613327
产品描述:
Widely used antitumor agent in vitro and in vivo. Deoxycytidine analog with cytotoxic effects. Inhibits DNA synthesis and induces apoptosis through inhibition of ribonucleotide reductase (R1 and R2). Following the uptake of this prodrug into cells by nucleoside transporters it is phosphorylated to its mono(dFdCMP), di(dFdCDP), and triphosphorylated(dFdCTP) forms by deoxycytidine kinase. dFdCDP and dFdCTP are reported to inhibit the activity of ribonucleotide reductase and impede DNA synthesis and repair mechanisms and induce cell death. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death. By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay at concentrations ranging from 34-134nM. This anticancer nucleoside analog inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40nM. It inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6 and NCI-H460 lung, and HS766T, PaCa-2, PANC-1, and BxPC-3 pancreatic cancer tumors in mouse xenograft models (45-93% inhibition). Also shown to block mitochondrial DNA polymerase gamma. Works synergistically with other chemotherapeutic agents to enhance their cytotoxicity. Has also broad antiretroviral activity, decreasing MuLV cell infectivity, a murine AIDS model, in cell culture (EC50 = ~1.5nM) and inhibits the progression of murine AIDS in vivo at a dose of 1-2 mg/kg per day.
宿主来源:
Synthetic.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
263.20 . 36.46
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at RT.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
122111-03-9
分子式:
C9H11F2N3O4 . HCl
溶解度:
Soluble in water (20mg/ml) or DMSO (slightly). Insoluble in ethanol.
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