官网链接
折扣/货期| 货号：GTX10305 | 规格：50μl | 目录价：￥6600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Gemin 3 antibody [12H12]
别名:
DEAD-box helicase 20 , DP103 , GEMIN3
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, ICC/IF, IP, WB
同种型:
IgG1
免疫原:
Recombinant 6His-tag C-terminal domain of Gemin 3 (amino acids 368-548).
克隆性:
Monoclonal
克隆号:
12H12
纯化方式:
Protein A Purified
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
The survival of motor neurons (SMN) gene is the disease gene of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The SMN protein is part of a complex containing several proteins, of which one, SIP1 (SMN interacting protein 1), has been characterized so far. The SMN complex is found in both the cytoplasm and in the nucleus, where it is concentrated in bodies called gems. In the cytoplasm, SMN and SIP1 interact with the Sm core proteins of spliceosomal small nuclear ribonucleoproteins (snRNPs), and they play a critical role in snRNP assembly. In the nucleus, SMN is required for pre-mRNA splicing, likely by serving in the regeneration of snRNPs. A DEAD box putative RNA helicase, named Gemin 3 which is another component of the SMN complex, has been identified. Gemin 3 interacts directly with SMN, as well as with SmB, SmD2 and SmD3. Immunolocalization studies using mAbs to Gemin 3 show that it colocalizes with SMN in gems. Gemin 3 binds SMN via its unique COOH-terminal domain, and SMN mutations found in some SMA patients strongly reduce this interaction. The presence of a DEAD box motif in Gemin 3 suggests that it may provide the catalytic activity that plays a critical role in the function of the SMN complex on RNPs.
您可能感兴趣的产品
4-hydroxy Nonenal Monoclonal Antibody (HNEJ-1/Clone IG10) - HRP Conjugated
货号：45025
ICAM4 antibody [HL5612]
货号：GTX646294
14-3-3 epsilon antibody [HL5606]
货号：GTX646288
Ras (Q61H mutant) antibody [HL5601]
货号：GTX646283
ALDH1L1 antibody [HL5536]
货号：GTX646210
AAV13 Capsid protein VP1 + VP2 + VP3 antibody [HL5535]
货号：GTX646198
ESAM antibody [HL5518]
货号：GTX646181
CD79a antibody [HL5516]
货号：GTX646179
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询