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折扣/货期| 货号：90-004 | 规格：50 ug | 目录价：￥9477 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GITRL, Soluble Recombinant Protein
别名:
Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18
产品浓度:
0.5mg/ml
表达系统:
HEK293 cells
保存温度:
Working aliquots are stable for up to 3 months when stored at -20˚C.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
0.2um-filtered solution in 10mM glycine, pH 10.0.
产地:
美国
生产商:
Prosci
功能与背景:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
纯度:
>90% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
生物活性:
Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
Accession #:
Q7TS55
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