官网链接
折扣/货期| 货号：SYN-1183-M001 | 规格：1 mg | 目录价：￥1204 |
| 货号：SYN-1183-M005 | 规格：5 mg | 目录价：￥1960 |
| 货号：SYN-1183-M010 | 规格：10 mg | 目录价：￥3024 |
| 货号：SYN-1183-M050 | 规格：50 mg | 目录价：￥10808 |
| 货号：SYN-1183-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GNF-5837
别名:
GNF5837
产品描述:
Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC(50) = 42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC(50) = 1 and 0.5µM) and Ba/F3-Tel-KDR and wt-Ba/F3 cells (IC(50) = 3.0 and 5.6µM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
535.5
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
1033769-28-6
分子式:
C28H21F4N5O2
您可能感兴趣的产品
T0901317
货号：SIH-643-50MG
T0901317
货号：SIH-643-10MG
Tauro-7-keto Deoxycholic Acid (sodium salt)
货号：9005003
(±)-6-epi Mesembrenol
货号：45823-1 mg
SMARCA-BD Ligand 1 for PROTAC (hydrochloride)
货号：45620-10 mg
1-Amino Hydantoin-13C3
货号：45619
4,4'-Dinitrocarbanilide-d8
货号：45610-1 mg
OPB-171775
货号：45601-10 mg
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询