GW501516-激动剂-深圳欣博盛生物科技有限公司

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GW501516

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3641-M001	规格：1 mg	目录价：￥询价
货号：AG-CR1-3641-M005	规格：5 mg	目录价：￥询价
货号：AG-CR1-3641-M025	规格：25 mg	目录价：￥询价

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GW501516

别名:

GSK-516; GW1516; Endurobol; 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid

产品描述:

Potent and selective peroxisome proliferator-activated receptor (PPAR) delta agonist/activator with high affinity (Ki=1nM) and potency (EC50=1nM) for PPARdelta and >1000 fold selectivity over PPARalpha and PPARgamma. The peroxisome proliferator-activated receptor delta (PPAR delta) has emerged as an important regulator of lipid homeostasis and inflammatory signaling. Recent in vitro, in vivo and human clinical studies have highlighted a role for PPARdelta activation in the prevention and treatment of insulin resistance and atherosclerosis. Antidiabetic compound. Shown to activate pathways initiated through exercise and was investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. Off-target high doses lead to tumor progression in rodents. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Increase serum HDL cholesterol and lowers small-dense LDL levels in obesity in vivo models. Reduces plasma triglyceride concentration. Increases expression of genes involved in lipid utilization, beta-oxidation, cholesterol efflux and energy uncoupling, as well as apolipoprotein-A1 specific efflux of intracellular cholesterol, indicating the muscle tissue is an important target. Model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

453.5

产品形式:

solid

产地:

瑞士

纯度:

>98% (NMR)