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折扣/货期| 货号：GTX12029 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HMGB1 antibody [HAP46.5]
别名:
high mobility group box 1 , HMG-1 , HMG1 , HMG3 , SBP-1
反应种属:
Chicken, Dog, Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG1
免疫原:
purified recombinant human HMG-1.
克隆性:
Monoclonal
克隆号:
HAP46.5
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
HMG1 and HMG2, chromatin non-histone high mobility group proteins 1 and 2, are 27 and 25 kDa members of a family of proteins containing multiple HMG-boxes, conserved domains of 80 amino acids which mediate DNA binding of many proteins. HMG box domains recognize DNA structure, such as prebent, supercoiled or four way junction DNA, and non- specific DNA sequences. Both HMG1 and HMG2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMG1/2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites, such as steroid hormone receptors, p53, and Oct. HMG1/2 may serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription and replication.
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