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折扣/货期| 货号：81-598 | 规格：100 ul | 目录价：￥8371.35 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Human IgM Rabbit Recombinant Antibody
别名:
MU; VH; AGM1; Human IgM
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB, IHC-P, ELISA
同种型:
IgG
克隆性:
Monoclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
Batch dependent
保存温度:
Store at -20℃. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
预期分子量:
75kDa
产品形式:
Liquid
存储溶液:
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
Accession #:
P01871
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