Human Recombinant Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-491XE

规格：500 µg (@5mg/ml)

目录价：￥20664

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils

别名:

Tau aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament- Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau protein fragment, Truncated Tau

产品描述:

Human Recombinant Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils

反应种属:

Human

实验应用:

WB | SDS-PAGE | In vitro Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml or 5 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

37 kDa

存储溶液:

10 mM Hepes pH 7.4, 100 mM NaCl

产地:

加拿大

功能与背景:

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons; only the shortest isoform of tau, 0N3R, is expressed in the fetal brain during neurogenesis (2). Three-repeat (3R) isoforms have been shown to be more prone than four-repeat (4R) isoforms to form oligomers in vitro (3). The β-sheet core of Tau 0N3R fibrilized using heparin differs from all other tau fibril structures known to date (4).

纯度:

>95%

Accession #:

NP_058525.1