Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-492B

规格：100 µg

目录价：￥5544

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

别名:

pyro abeta, pyro amyloid beta, Abeta, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, pyroglutamate amyloid beta, AβPE3, APP

产品描述:

Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

N/A

偶联:

No Tag

产品浓度:

1 mg/ml

表达系统:

N/A

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

4.3 kDa

存储溶液:

10mM HCl with 2% DMSO

产地:

加拿大

功能与背景:

Our Amyloid Beta pyroglutamate 3-42 (pyro Aβ) Pre-formed Fibrils are generated from Amyloid Beta Peptide 3-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) using a previously published method (1,2). Our pyro Aβ3-42 fibrils present as primarily long strands when observed under TEM and AFM, and have a unique high molecular weight signal on a Western Blot with an anti-amyloid beta antibody. Amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Pyroglutamate Aβ 3-42 is an N-terminally truncated peptide species that is modified by glutaminyl cyclase and has been reported to compromise 15-45% of total amyloid beta deposits in brains of AD patients (4,5). Pyroglutamate Aβ 3-42 exhibits higher aggregation propensity and neurotoxicity compared with full-length Aβ 1-42 (6,7) and is an active target in the next generation AD therapeutic development (8).

纯度:

>95%