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折扣/货期| 货号：AG-CN2-0008-C500 | 规格：500 ug | 目录价：￥1440 |
| 货号：AG-CN2-0008-M001 | 规格：1 mg | 目录价：￥2160 |
产品详情
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产品名称:
Hyperforin . DCHA
别名:
(1R,5R,6R,7S)-2-Hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione . DCHA
产品描述:
Key constituent of St. John's wort. Shows properties of potential pharmacological interest, including antibacterial [1], anti-malarial [13], anti-inflammatory [7, 14], anti-cancer and anti-angiogenic effects [5, 10]. Anti-depressant and anxiolytic compound [3]. Specific activator of TRPC6 channels [11]. Inhibits the re-uptake of neurotransmitters in synapses (serotonin, norepinephrine, dopamine, GABA, glutamate) [4]. Activator of the pregnane X receptor (PXR) [2]. Regulates expression of the cytochrome P450 CYP3A4 and CYP2C9 and hepatic drugs metabolism [8]. Potential anti-Alzheimer compound [6, 9, 15]. Potent SIRT1 (sirtuin 1) and SIRT2 (sirtuin 2) inhibitor [12]. Based on the anti-inflammatory activity of Hyperforin and its simultaneous blockade of multiple signaling pathways, such as IFN‐gamma/IL‐1beta/TNF‐alpha, JAK/STAT, NF‐kappaB and MAPK it has been suggested a valuable agent for cytokine storm treatment during COVID-19 [16].
宿主来源:
Isolated from St. John's wort (Hypericum perforatum).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
535.8 . 182.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>97% (HPLC)
CAS号:
238074-03-8
分子式:
C35H51O4 . C12H24N
溶解度:
Soluble in 100% ethanol, methanol or DMSO.
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