IAXO-101 (CD14/TLR4 Antagonist) (synthetic)-其他小分子化合物-深圳欣博盛生物科技有限公司

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IAXO-101 (CD14/TLR4 Antagonist) (synthetic)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：IAX-600-001-M001

规格：1 mg

目录价：￥3864

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IAXO-101 (CD14/TLR4 Antagonist) (synthetic)

别名:

Methyl 6-deoxy-6-N-dimethyl-N-cyclopentylammonium-2,3-di-O-tetradecyl-alpha-D-glucopyranoside iodide

产品描述:

CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.

宿主来源:

Synthetic.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

810.02g/mol (iodide salt)

产品形式:

solid

产地:

瑞士

纯度:

>98% (TLC)

生物活性:

Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g. CD36) as well as on type and time of read-out (e.g. cytokine measurement in cell culture supernatant) or the biological outcome of in vivo experiments and therefore needs to be determined for each application. Recommended starting concentration: in vitro: 5µM, in vivo (rodent): 3mg/kg.

CAS号:

1202388-64-4

分子式:

C42H84INO5

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