IL12 Receptor beta1 antibody-多抗-深圳欣博盛生物科技有限公司

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IL12 Receptor beta1 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10781

规格：25μg

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IL12 Receptor beta1 antibody

别名:

interleukin 12 receptor subunit beta 1 , CD212 , IL-12R-BETA1 , IL12RB , IMD30

反应种属:

Human

宿主来源:

Goat

实验应用:

ELISA, WB

靶标/特异性:

The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.

同种型:

IgG

免疫原:

recombinant human IL-12 Rβ1 extracellular domain, expressed in NSO cells

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

Interleukin 12 (IL12) was identified as a factor secreted by human Epstein-Barr (EBV) transformed B cell lines. IL12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL12 is produced predominantly by monocytes and NK cells2 and induces T cells and NK cells to produce IFN gamma. Human IL12 is not active on mouse cells, but murine IL12 is active on both murine and human lymphocytes. IL12 signals through the IL12 receptor, which is composed of at least two subunits designated beta1 and beta2. Both IL12 receptor subunits are members of the hemapoietin receptor superfamily and have strong homology to the gp130 receptor. The beta1 receptor, although a low affinity binder of IL12, is not capable of transducing an IL12-mediated signal. A second subunit of the IL12 receptor was subsequently identified that when coexpressed with the beta1 subunit forms a high affinity receptor for IL12 and confers IL12 signaling.

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