IL18 Receptor 1 antibody-多抗-深圳欣博盛生物科技有限公司

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IL18 Receptor 1 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10787

规格：25μg

目录价：￥6600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IL18 Receptor 1 antibody

别名:

interleukin 18 receptor 1 , CD218a , CDw218a , IL-1Rrp , IL18RA , IL1RRP

反应种属:

Human

宿主来源:

Goat

实验应用:

ELISA, WB

同种型:

IgG

免疫原:

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

Interleukin 18, also known as interferon-gamma inducing factor (IGIF) and IL1 gamma, shares some biologic activities with IL12 and structural similarities with the IL1 family of proteins. It plays an important role in the T cell helper type 1 (Th1) response through its ability to induce IFN-gamma production in T cells and NK cells. IL18 is related to the IL1 family in terms of structure, receptor family and function. Structurally, IL18 and IL1-beta share primary amino acids sequences (signature sequence motif) and are similarly folded as all-beta pleated sheet molecules. Similar to IL1 beta, production of IL18 requires caspase 1 (interleukin 1-beta converting enzyme, ICE) to cleave the pro-domain from the precursor protein to produce active mature IL18. Gene expression and synthesis of TNF, IL1, Fas ligand and several chemokines are induced by IL18. As with IL1, IL18 participates in both innate and acquired immunity. IL18 actions are mediated by an IL18 receptor (IL18R1) complex comprised of a binding chain (IL18 R-alpha, also called IL1 receptor-related protein, IL1 Rrp) and a signal-transducing chain. Both chains are members of the IL1 receptor family. The IL18R1 complex recruits the IL1 R-activating kinase (IRAK) and TNFR associated factor 6 (TRAF6) which phosphorylates NF-kappa-B-inducing kinase (NIK) with subsequent activation of NF-kappa-B.

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