Itraconazole-其他小分子化合物-深圳欣博盛生物科技有限公司

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Itraconazole

品牌：Adipogen

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说明书

折扣/货期

货号：CDX-I0072-M100

规格：100 mg

目录价：￥1582

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Itraconazole

别名:

Oriconazole; R 51211; Triasporin; cis-Itraconazole; Fungitraxx

产品描述:

Itraconazole is a broad-spectrum triazole antifungal agent widely used in clinical and research applications for its ability to inhibit fungal ergosterol synthesis by targeting the cytochrome P450 enzyme lanosterol 14alpha-demethylase and compromising the cell membrane, which leads to its fungicidal activity. It is effective against a range of pathogenic fungi, including Aspergillus, Candida, and Histoplasma species, making it valuable for studying antifungal mechanisms and resistance. Beyond its antifungal properties, Itraconazole has anti-angiogenic and Hedgehog pathway-inhibiting effects and has gained interest in cancer research. Itraconazole has inhibitory activity on Smoothened (SMO) at different binding site to cyclopamine, thereby disrupting the signaling in Hedgehog pathway. It has been extensively investigated for its potential repurposing across various cancers, such as basal cell carcinoma, prostate cancer, non-small cell lung cancer, breast cancer, medulloblastoma, glioblastoma and pancreatic cancer.

宿主来源:

Synthetic

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

705.63

产品形式:

solid

产地:

瑞士