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折扣/货期| 货号：AG-MR-C0023-M001 | 规格：1 mg | 目录价：￥780 |
| 货号：AG-MR-C0023-M005 | 规格：5 mg | 目录价：￥2760 |
| 货号：AG-MR-C0023-M025 | 规格：25 mg | 目录价：￥10680 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Leucettine L41
别名:
(5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
产品描述:
Potent inhibitor of DYRKs (DYRK1A (IC50=40nM); DYRK2 (IC50=35nM)) and CLKs (CLK1, CLK3). Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Autophagy activator.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
307.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
1112978-84-3
分子式:
C17H13N3O3
溶解度:
Soluble in DMSO or ethanol.
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