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折扣/货期| 货号：SIH-120A | 规格：1 mg | 目录价：￥1670.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MAPKII Kinase Inhibitor
产品描述:
Hsp25 Kinase Inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
1396.7
产品形式:
White Solid
产地:
加拿大
功能与背景:
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). In particular, MAPKAP-kinase II (or otherwise known as MK2) is involved in inflammation, and is considered a target for therapeutic intervention for inflammation and cancer (3). MK2 is a member of the p38 MAPKinase pathway, and is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (3).
纯度:
>95%
来源:
Synthetic
分子式:
C61H113N21O6
溶解度:
Soluble in DMSO or H20
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