YM-01-抑制剂-深圳欣博盛生物科技有限公司

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YM-01

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SIH-121-10MG

规格：10 mg

目录价：￥2721.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

YM-01

别名:

2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride; YM-1

产品描述:

Hsp70 Inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

417.97

产品形式:

Orange red solid

产地:

加拿大

功能与背景:

YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

纯度:

>98% (HPLC)

来源:

Synthetic

CAS号:

409086-68-6

分子式:

C20H20ClN3OS2

溶解度:

Soluble in warm water (2 mg/ml)

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