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折扣/货期| 货号：SYN-1054-M001 | 规格：1 mg | 目录价：￥2954 |
| 货号：SYN-1054-M005 | 规格：5 mg | 目录价：￥7336 |
| 货号：SYN-1054-M010 | 规格：10 mg | 目录价：￥10514 |
| 货号：SYN-1054-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1054-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Merck-5
别名:
Pyridone 6
产品描述:
Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5. In research comparing Merck 5 (Pyridone 6) to the Jak inhibitor AG490, Merck 5 demonstrated much lower effective drug concentrations and faster kinetics and appear to be a more sensitive and specific inhibitor of JAK-STAT3 activity compared with AG490 and potently inhibited the growth of primary myeloma cells and myeloma-derived cell lines grown on bone marrow-derived stromal cells .
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
309.3
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
457081-03-7
分子式:
C18H16FN3O
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