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折扣/货期| 货号：CDX-M0183-M050 | 规格：50 mg | 目录价：￥882 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Mevastatin
别名:
Compactin; 6-Demethylmevinolin; CS-500; ML-236B; L-637,312; NSC 281245; Statin I
产品描述:
Mevastatin is an antibiotic that is a competitive HMG-CoA reductase inhibitor, thus suppressing Ras farnesylation. Mevastatin decreases cholesterol biosynthesis in vitro and in vivo. It induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Mevastatin also suppresses TNF-induced NF-kappaB activation and potentiates apoptosis in human myeloid leukemia cells. Mevastatin induced neurite outgrowth of neuroblastoma cells via activation of EGFR, ERK1/2 and Akt/PBK but also exerts a neurotoxic effect in cultured neurons in a heme-independent manner. Mevastatin also shows antileishmanial and antifungal activity. Has also anti-inflammatory effects potentially via up-regulation of heme oxygenase-1 (HO-1).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
390.51
产品形式:
solid
产地:
瑞士
纯度:
>95% (NMR)
CAS号:
73573-88-3
分子式:
C23H34O5
促销活动
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