MGMT Antibody-单抗-深圳欣博盛生物科技有限公司

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MGMT Antibody

品牌：NSJ Bio

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说明书

折扣/货期

货号：V4036-100UG	规格：100 ug	目录价：￥6414.1
货号：V4036-20UG	规格：20 ug	目录价：￥2963.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MGMT Antibody

产品描述:

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross links at the O6 alkylguanine position in DNA. MGMT transfers alkyl adducts from the O6 position of guanine in DNA (prior to cross link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely to be drug resistant

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG1

免疫原:

Purified His-tagged MGMT protein was used as the immunogen for the MGMT antibody.

克隆性:

Monoclonal (mouse origin)