SMAD4 Antibody-单抗-深圳欣博盛生物科技有限公司

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SMAD4 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V4035SAF-100UG

规格：100 ug

目录价：￥6414.1

产品详情

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产品名称:

SMAD4 Antibody

产品描述:

Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4.Upon ligand binding, the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80% of cases of pancreatic adenocarcinoma, but rarely in endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2%) adenocarcinomas, and malignant melanoma (4%). SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG1, kappa

免疫原:

Full-length human protein (amino acids 1-552) was used as the immunogen for the recombinant SMAD4 antibody.

克隆性:

Recombinant Mouse Monoclonal