Mitotane-其他小分子化合物-深圳欣博盛生物科技有限公司

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Mitotane

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-D0724-M250

规格：250 mg

目录价：￥742

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mitotane

别名:

2,4'-DDD; o,p'-DDD; 2,4'-Dichlorodiphenyl)dichloroethane; o,p'-TDE; CB 313; NSC 38721; Opeprim

产品描述:

Mitotane (o,p'DDD) is an adrenocorticolytic agent primarily used in research related to adrenal gland disorders, especially adrenocortical carcinoma (ACC). Mitotane is an inhibitor of steroidogenesis and mitochondrial complex IV, also known as cytochrome c oxidase. It selectively targets adrenal cortex cells by disrupting mitochondrial function and steroidogenesis, leading to cytotoxic and endocrine-suppressive effects. Mitotane is a selective inhibitor of sterol-Oacyl-transferase 1 (SOAT1), also known as ACAT1, (acyl-coenzyme A cholesterol acyltransferase). Mitotane inhibits enzymes involved in cortisol synthesis, such as CYP11A1 and CYP11B1, and induces adrenal atrophy. Mitotane acts through mitochondrial toxicity (induction of apoptosis), inhibition of cell proliferation in ACC, inhibition of steroidogenic enzymes, and selective adrenal cytotoxicity, making it effective in treating adrenocortical carcinoma and Cushing's syndrome. Compound can be used as analytical reference material.

宿主来源:

Synthetic

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

320.04

产品形式:

solid

产地:

瑞士