MMP1 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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MMP1 Recombinant Protein

品牌：ProSci LLC

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说明书

折扣/货期

货号：96-537

规格：0.05 mg

目录价：￥9477

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MMP1 Recombinant Protein

别名:

MMP1, CLG, CLGN

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

20 mM MES, 150 mM NaCl, 10 mM CaCl2, pH6.0 with 0.05% Brij-35

产地:

美国

生产商:

Prosci

功能与背景:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) is also known as interstitial collagenase and fibroblast collagenase. MMP1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 breaks down the interstitial collagens, types I, II, and III. MMP1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, myelin basic protein, LSelectin, proTNF, IL1β, IGFBP3, IGFBP5, pro MMP2 and pro MMP9.

纯度:

>90% as determined by SDS-PAGE.

生物活性:

Measured by its ability to cleave a fluorogenic peptide substrate Mca - KPLGL - Dpa - AR - NH2. The specific activity is > 200 pmol/min/μg.

Accession #:

NP_002412.1

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