MXI1 Antibody / Max-interacting protein 1 / BHLHC11-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

MXI1 Antibody / Max-interacting protein 1 / BHLHC11

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V9204SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MXI1 Antibody / Max-interacting protein 1 / BHLHC11

产品描述:

It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

反应种属:

Human

宿主来源:

Mouse

实验应用:

FACS, IF, WB

同种型:

Mouse IgG2b

免疫原:

Recombinant full-length human MXI1 protein was used as the immunogen for the MXI1 antibody.

克隆性:

Monoclonal (mouse origin)