N-(3-Oxododecanoyl)-DL-homoserine lactone-其他小分子化合物-深圳欣博盛生物科技有限公司

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N-(3-Oxododecanoyl)-DL-homoserine lactone

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-O0032-M010	规格：10 mg	目录价：￥966
货号：CDX-O0032-M020	规格：20 mg	目录价：￥1666
货号：CDX-O0032-M100	规格：100 mg	目录价：￥4284

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

N-(3-Oxododecanoyl)-DL-homoserine lactone

别名:

OdDHL; 3O-C12-DL-HSL; 3-oxo-C12-HSL; 3OC12HSL; n-(3-Oxododecanoyl) DL-homoserine lactone; 3-Oxo-N-(tetrahydro-2-oxo-3-furanyl)dodecanamide; 3-Oxo-N-(2-oxooxolan-3-yl)dodecanamide

产品描述:

Quorum sensing agent. N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) is a small diffusible signaling molecule, also identified as P. aeruginosa autoinducer (PAI), and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention and formation of biofilms. 3-oxo-C12-HSL is one of the AHLs frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa. 3-oxo-C12-HSL activates the transcription factors NF-kappaB and AP-2 to induce interleukin-8, cyclooxygenase 2, and prostaglandin E2 production in human lung fibroblasts and epithelial cells, possibly contributing to the neutrophil infiltration and inflammation found in P. aeruginosa infections. 3-oxo-C12-HSL also suppresses human and murine leucocyte proliferation and inhibits LPS-induced secretion of TNF-R and IL-12. 3-oxo-C12-HSL accelerated apoptosis in mammalian macrophages and neutrophils and shown to inhibit the growth of human colorectal, breast and prostate cancer cells.

宿主来源:

Synthetic

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

297.39

产品形式:

solid

产地:

瑞士