Nimbolide -其他小分子化合物-深圳欣博盛生物科技有限公司

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Nimbolide

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-N0360-M005

规格：5 mg

目录价：￥3150

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Nimbolide

别名:

NSC 309909

产品描述:

Nimbolide is a limonoid tetranortriterpenoid shown to exhibit anti-malarial, anti-bacterial, anti-inflammatory, anti-obesity and anti-cancer activities. Nimbolide induces cell cycle arrest, DNA damage and apoptosis, and modulates autophagy in cancer cell lines. It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3 and PARP. Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. This compound impairs proliferation of triple-negative breast cancer cell lines. Nimbolide also induces apoptotic cell death in a Waldenstroms macroglobulinemia cell line (BCWM1) and inhibits tumor growth in a xenograft model of Waldenstroms macroglobulinemia. Nimbolide can be used for the development of Degraders that utilize RNF114 as an E3 ligase for Targeted Protein Degradation. Nimbolide exerts protective effects in complete Freund's adjuvant induced inflammatory arthritis via abrogation of STAT-3/NF-?B/Notch-1 signaling. Nimbolide suppresses high fat diet (HFD) induced obesity via the Nrf2/HO-1 pathway.

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

466.52

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)