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折扣/货期| 货号：GTX28387 | 规格：200μl | 目录价：￥9500 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NOTCH1 antibody
别名:
notch receptor 1 , AOS5 , AOVD1 , TAN1 , hN1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
ELISA, IHC-P, WB
靶标/特异性:
Notch1 antibody is directed against human NOTCH 1. No reaction is detected against NOTCH 2. No reactivity was observed against Mouse Notch. Other species have not been tested.
同种型:
IgG
免疫原:
Synthetic peptide corresponding to an internal region near amino acid 2480-2510 of human Notch 1.
克隆性:
Polyclonal
克隆号:
偶联:
Unconjugated
产品浓度:
75 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
273
产品形式:
Liquid
存储溶液:
20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
Notch-1 is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
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