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折扣/货期| 货号：AG-CN2-0537-M005 | 规格：5 mg | 目录价：￥2520 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Oleocanthal
别名:
(-)-Oleocanthal; 2-(4-Hydroxyphenyl)ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate; Deacetoxy Ligstroside Aglycon; p-HPEA-EDA
产品描述:
Oleocanthal is a naturally occurring amphiphilic secoiridoid from olive oil, with potent anti-inflammatory, antioxidant, anticancer and neuroprotective properties. Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX-1, COX-2) enzymes in the prostaglandin biosynthesis. It also has been shown to inhibit the NLRP3 inflammasome. Inhibits proliferation, migration and invasion of various cancer cells while leaving healthy cells unharmed. It shows selective cytotoxicity, inducing lysosomal membrane permeabilization in cancer cells. It inhibits the enzymatic activity of mammalian target of rapamycin (mTOR), and the tyrosine kinase receptor c-Met (responsible for proliferation of many cell types) and Hsp90, consequently leading to cell cycle arrest during G1 phase. The neuroprotective activity includes the reduction of beta-amyloid protein accumulation via up-regulation of P-glycoprotein and LRP1, altering the fibrillization of tau proteins, key factors at the basis of neurodegenerative diseases and reducing oxidative stress. Activator of the TRPA1 ion channel, responsible for the burning sensation that occurs in the back of the throat when consuming such oil. Shows antimicrobial activities.
宿主来源:
Isolated from Olea europaea.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
304.3
产品形式:
liquid
产地:
瑞士
纯度:
>97% (HPLC)
CAS号:
289030-99-5
分子式:
C17H20O5
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