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折扣/货期| 货号：CDX-O0207-M010 | 规格：10 mg | 目录价：￥1050 |
| 货号：CDX-O0207-M050 | 规格：50 mg | 目录价：￥3150 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ONC212
别名:
TR-31; 7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one; NSC-783745
产品描述:
ONC212 is a potent imipridone small-molecule (and fluorinated imipridone analog of ONC201) that acts as a dual agonist of the mitochondrial protease ClpP and the orphan GPCR GPR132, provoking mitochondrial dysfunction, integrated stress response, and apoptotic cell death, particularly in acute leukemia and solid tumor models. By targeting the mitochondrial protease ClpP, this engagement disrupts mitochondrial function, impairs oxidative phosphorylation and contributes to its anti-tumor activity across diverse preclinical cancer models. Acting as an agonist of the orphan G protein-coupled receptor GPR132, triggering downstream Galphaq signaling and the integrated stress response, contributes to its pronounced anti-leukemic effects, particularly in acute myeloid leukemia models.
宿主来源:
Synthetic
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
440.5
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1807861-48-8
分子式:
C24H23F3N4O
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