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折扣/货期| 货号：GTX80360 | 规格：50μl | 目录价：￥7600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ORC1 antibody [7A7]
别名:
origin recognition complex subunit 1 , HSORC1 , ORC1L , PARC1
反应种属:
Human
宿主来源:
Rat
实验应用:
IP, WB
靶标/特异性:
Human ORC1
同种型:
IgG1
免疫原:
ORC1 (hsORC)
克隆性:
Monoclonal
克隆号:
7A7
纯化方式:
Protein G
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
97
产品形式:
Liquid
存储溶液:
PBS, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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