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折扣/货期| 货号：GTX21431 | 规格：50μg | 目录价：￥4700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
p53 (phospho Ser15) antibody
别名:
tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, ICC/IF, IHC, IHC-P, IP, WB
靶标/特异性:
The phospho-p53 (Ser15) antibody detects ~53 kDa phosphorylated p53 at Ser15. It does not react with non-phosphorylated p53 or p53 phosphorylated at other sites.
同种型:
IgG
免疫原:
Synthetic phospho-peptide surrounding amino acid Ser 15 of human p53.
克隆性:
Polyclonal
克隆号:
偶联:
Unconjugated
产品浓度:
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
44
产品形式:
Liquid
存储溶液:
PBS, 0.5% BSA, 30% Glycerol, 0.01% Thimerosal.
生产商:
GeneTex
功能与背景:
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.
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