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折扣/货期| 货号：GTX11101 | 规格：100μl | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Paxillin antibody [PXC-10]
别名:
paxillin , TGFB1I1
反应种属:
Bovine, Chicken, Hamster, Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
ICC/IF, WB
靶标/特异性:
Recognizes an epitope located in the LIM1 domain of the paxillin molecule.
同种型:
IgG1
免疫原:
C-terminal part of recombinant chicken paxillin (amino acids 305-559)
克隆性:
Monoclonal
克隆号:
PXC-10
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Cellular adhesion to the extracellular matrix is critically involved in many processes including normal and transformed cell growth, migration, metastasis, lymphocyte extravasation and also in force transmission during muscle contraction. Paxillin (68 kDa), is a cytoskeletal component found in the focal adhesions at the ends of actin stress fibers, but not in adherens junctions of the cells. Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for FAK, that are separated by an intervening sequence of 100 amino acids. Upon transformation by RSV, 20-30% of the paxillin molecules are phosphorylated on tyrosine. In addition, the cellular distribution of paxillin becomes more diffuse, suggesting that phosphorylation of paxillin may have a role in the disassembly of focal adhesions and stress fibers during transformation. The availability of monoclonal antibody reacting specifically with paxillin enables the subcellular detection and localization of paxillin.
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