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折扣/货期| 货号：AG-CR1-3748-M010 | 规格：10 mg | 目录价：￥480 |
| 货号：AG-CR1-3748-M050 | 规格：50 mg | 目录价：￥1080 |
| 货号：AG-CR1-3748-M250 | 规格：250 mg | 目录价：￥3000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Pazopanib . hydrochloride
别名:
GW-786034; GW786034B; GSK-VEG10003; Votrient; Armala
产品描述:
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor. It is an orally available angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit. It inhibits the VEGF receptors VEGFR1, VEGFR2 and VEGFR3 (IC50s = 10, 30 and 47 nM, respectively, in a cell-free enzyme assay) and also inhibits PDGFR, FGFR, c-Kit and c-fms with IC50 values of 84nM, 74nM, 140nM and 146nM, respectively, all key proteins responsible for tumor growth and angiogenesis. Pazopanib is an anti-tumor and anti-angiogenic agent. It inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells co-cultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells co-cultured with HUVECs. Pazopanib reduces tumor growth, induces apoptosis, decreases angiogenesis and increases survival in vivo in multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
437.5 . 36.5
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
635702-64-6
分子式:
C21H23N7O2S . HCl
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