货号:AG-CR1-0162-M001 | 规格:1 mg | 目录价:¥240 |
货号:AG-CR1-0162-M005 | 规格:5 mg | 目录价:¥420 |
货号:AG-CR1-0162-M025 | 规格:25 mg | 目录价:¥1440 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
PK150 (Sorafenib Analog)
别名:
Antibiotic PK150; 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)urea
产品描述:
Analog of the anticancer drug sorafenib. PK150 is a potent antibiotic. It shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively. PK150 did not induce in vitro resistance and shows oral bioavailability and in vivo efficacy. The mode of action includes the interference with menaquinone biosynthesis by inhibiting demethylmenaquinone methyltransferase and the stimulation of protein secretion by altering the activity of signal peptidase IB.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
394.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
2165324-62-7
分子式:
C15H8ClF5N2O3
溶解度:
Soluble in DMSO (25mg/ml).
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