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折扣/货期| 货号：AG-CN2-0010-M001 | 规格：1 mg | 目录价：￥456 |
| 货号：AG-CN2-0010-M005 | 规格：5 mg | 目录价：￥1296 |
| 货号：AG-CN2-0010-M010 | 规格：10 mg | 目录价：￥1920 |
| 货号：AG-CN2-0010-M025 | 规格：25 mg | 目录价：￥3600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PMA
别名:
PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate
产品描述:
PMA/TPA is the most commonly-used phorbol ester [1,2]. Binds to and activates protein kinase C (PKC) at nM concentrations [1,2,9]. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter [3,4]. Promoter of inducible NOS (iNOS; NOS II) [5]. Apoptosis inducer [6]. Potential effective cancer therapeutic agent [7,8]. Inhibitor of anti-lipolytic activity of insulin [10]. PMA treatment stimulates THP-1 cells and generates M0 macrophages (M0).
宿主来源:
Semisynthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
616.8
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
16561-29-8
分子式:
C36H56O8
溶解度:
Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml), methanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
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