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折扣/货期| 货号：AG-CR1-3595-M025 | 规格：25 mg | 目录价：￥660 |
| 货号：AG-CR1-3595-M100 | 规格：100 mg | 目录价：￥1560 |
| 货号：AG-CR1-3595-M500 | 规格：500 mg | 目录价：￥4680 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Propionyl-L-carnitine . hydrochloride
别名:
PLC
产品描述:
Naturally occurring carnitine derivative formed by carnitine acetyltransferase during beta-oxidation of uneven chain fatty acids, with high affinity for muscular carnitine transferase. Increases cellular carnitine content, allowing free fatty acid transport into the mitochondria [1, 5]. Stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity [1, 2]. Important for mitochondrial metabolism and energy regulation. Regulates the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation [9, 11]. Selectively inhibits in vitro and ex vivo platelet-activating factor (PAF) synthesis from human neutrophils [3]. Antioxidant. Shows free radical scavenging activity [4]. Decreases the expression of inducible nitric oxide synthase (iNOS/NOS II) and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells [7]. Shows beneficial cardiovascular effects. Improves body weight, food intake, adiposity and insulin resistance in Type 2 diabetes [5, 6, 8-10]. Stimulates endothelial nitric oxide (eNOS/NOS III) and increased NO production, via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt [6, 12].
宿主来源:
Synthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
217.3 . 36.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
119793-66-7
分子式:
C10H19NO4 . HCl
溶解度:
Soluble in water, methanol, ethanol, DMSO or dimethyl formamide.
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