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折扣/货期| 货号：IAX-700-109-L001 | 规格：1 ml | 目录价：￥3192 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Retinoic Acid Sterile Solution
别名:
Retinoic Acid Lipodisq™ Sterile Solution; Tretinoin; all-trans-Retinoic acid (ATRA); Vitamin A acid in a detergent-free nano-formulation made of styrenemaleic acid lipid particles (SMA-Lipid Particles)
产品描述:
Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. All-transretinoic acid (ATRA) and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin. All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors (RARs). These included two families of receptors, the RAR isotypes (a,b, and g) along with three RXR isotypes (a,b, and g), which bind as RXR/RAR heterodimers to cis-acting response elements of RA target genes to generate a high degree of complexity. Retinoic acid is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba.
产品浓度:
1mg/ml (0.1% w/vol)
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
300.44
产品形式:
liquid
存储溶液:
Liquid, detergent-free discoidal nano-formulation made of styrene-maleic acid lipid particles (SMALP), lecithin and sterile water.
产地:
瑞士
纯度:
>95% (HPLC)
生物活性:
Discoidal nano-particles can incorporate hydrophobic, poorly water-soluble compounds, such as lipids, lipoproteins and glycolipids.- Cell culture tested (human macrophage cell line) (MTT). - Recommended starting dilution: 1:200 or higher. - Optimal working concentrations depend on the applications and need to be determined. - Published procedures using Lipodisq formulations (Curcumin and IAXO TLR4 antagonists) in vivo rodent models at 3-10mg/kg. Recommended route of administration is subcutaneous (s.c.) with oral or nasal application as a possible alternative, which needs to be optimized.
分子式:
C20H28O2
促销活动
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