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折扣/货期| 货号：AG-CR1-3653-M002 | 规格：2 mg | 目录价：￥1320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RF-22c [5-Lipoxygenase Inhibitor]
别名:
3-Dodecyl-4,5-dimethoxy-3,5-cyclohexadiene-1,2-dione; 5-LO Inhibitor RF-22c
产品描述:
Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.
宿主来源:
Synthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
336.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1680206-61-4
分子式:
C20H32O4
溶解度:
Soluble in DMSO (1mg/ml), ethanol or chloroform. Insoluble in water.
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