RNA pyrophosphohydrolase Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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RNA pyrophosphohydrolase Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：92-618

规格：0.05 mg

目录价：￥9038.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

RNA pyrophosphohydrolase Recombinant Protein

别名:

RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase, Ap5A pyrophosphatase, rppH

表达系统:

E. coli

保存温度:

Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

运输温度:

Dry Ice

产品形式:

Liquid

存储溶液:

Supplied as a 0.2 um filtered solution of 50mM Tris, 500mM NaCl, 10% glycerol, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

产地:

美国

生产商:

Prosci

功能与背景:

Messenger RNA (mRNA) degradation plays a key role in the control of gene expression in all organisms by limiting the number of times that each mRNA molecule can be used as a template for protein synthesis. RNA pyrophosphohydrolase, also called RppH, is a master regulator of 5'-dependent mRNA decay. It accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. RppH preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products, and can be able to hydrolyze diadenosine hexa- and tetra-phosphate. However, this protein has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E. coli K1, it has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.

纯度:

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Accession #:

P0A776

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