Rotenone-其他小分子化合物-深圳欣博盛生物科技有限公司

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Rotenone

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0516-G001	规格：1 g	目录价：￥540
货号：AG-CN2-0516-G005	规格：5 g	目录价：￥1176

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Rotenone

别名:

Nicouline; NSC 8505; NSC 26258; Tubatoxin

产品描述:

Cell permeable reversible and competitive mitochondrial electron transport chain complex I (NADH-CoQ reductase) inhibitor (IC50=1.7-2.2µM). Inhibits NADH/DB oxidoreductase and NADH oxidase and consequently oxidative phosphorylation (OXPHOS). Specifically inhibits NAD-linked substrate oxidation of NADH dehydrogenase. Useful agent for immunometabolism research. Inhibition of electron transport chain in mitochondria leads to blocking of the transfer of electrons from iron-sulfur centers in complex I to ubiquinone. This interferes with NADH during the creation of usable cellular energy (ATP), and Complex I is unable to pass off its electron to CoQ, creating a back-up of electrons within the mitochondrial matrix. Cellular oxygen is reduced to the radical, creating reactive oxygen species, which can damage DNA and other components of the mitochondria. Shown to inhibit mammalian cell proliferation, via suppressing microtubule assembly by binding to tubulin and inhibiting autophagy induction, by blocking lysosomal degradation of autophagic vacuoles. Shown to induce cell cycle arrest and apoptosis through production of mitochondrial ROS, consequently leading to induction of oxidative stress. Used to induce Parkinson's diseases-like syndrome in experimental animal model. Selective priming signal for NLRP3 inflammasome activation in combination with ATP, but not with Nigericin or MSU. Commonly used as a broad spectrum insecticide, piscicide and pesticide.

宿主来源:

Isolated from Fabaceae species.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

394.4

产品形式:

solid

产地:

瑞士