(S)-(+)-Camptothecin-其他小分子化合物-深圳欣博盛生物科技有限公司

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(S)-(+)-Camptothecin

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0463-M050	规格：50 mg	目录价：￥300
货号：AG-CN2-0463-M250	规格：250 mg	目录价：￥1080

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

(S)-(+)-Camptothecin

别名:

CPT; NSC 94600

产品描述:

Potent anticancer compound. Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor. Potent apoptosis inducer. Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, consequently depleting cellular topoisomerase I. Prevents DNA re-ligation and therefore causes DNA damage which results in apoptosis. Inhibits mitochondrial topoisomerase I (mtTop1). Blocks the cell cycle at low dose and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes. Antiprotozoal and antimalarial compound. Inhibitor of HIV replication and of other viruses. Suppresses nitric oxide (NO) biosynthesis. Shown to suppress TNF-alpha-induced expression of the inflammasome and cyclooxygenase 2 (COX-2).

宿主来源:

Isolated from Camptotheca acuminata.

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

348.4

产品形式:

solid

产地:

瑞士