S-Adenosylmethionine-其他小分子化合物-深圳欣博盛生物科技有限公司

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S-Adenosylmethionine

品牌：Adipogen

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说明书

折扣/货期

货号：CDX-A0247-M050	规格：50 mg	目录价：￥3500
货号：CDX-A0247-M100	规格：100 mg	目录价：￥5684

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

S-Adenosylmethionine

别名:

SAM; SAMe; AdoMet; Ademethionine; S-Adenosyl-L-Methionine

产品描述:

S-Adenosylmethionine (SAM) is the first product of the methionine cycle and is implicated in the synthesis of polyamines and in the transsulfuration pathway leading to homocysteine and reduced glutathione (GSH) biosynthesis. SAM is synthesized from methionine and ATP in a reaction catalyzed by methionine adenosyltransferases (MATs). These enzymes are encoded by two genes, MAT1A and MAT2A. SAM plays an essential role as methyl-donor for the methylation reactions during which it is transformed to S-adenosylhomocysteine (SAH). SAH, a strong inhibitor of transmethylations, is transformed to homocysteine (HCY) by a specific hydroxylase. The methionine cycle plays a fundamental role in the cellular metabolism and the alteration of its functionality causes important disorders linked to modification of DNA methylation and gene expression, redox imbalance and metabolic reprogramming in liver and brain. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, SAM serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule. SAM is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research.

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

398.44

产品形式:

solid

产地:

瑞士

纯度:

>95% (NMR)