S-Benzoylthiamine O-monophosphate-其他小分子化合物-深圳欣博盛生物科技有限公司

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S-Benzoylthiamine O-monophosphate

品牌：Adipogen

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说明书

折扣/货期

货号：CDX-B0403-G001	规格：1 g	目录价：￥1106
货号：CDX-B0403-G005	规格：5 g	目录价：￥4060

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

S-Benzoylthiamine O-monophosphate

别名:

Benfotiamine; Benzoylthiamine monophosphate

产品描述:

S-Benzoylthiamine O-monophosphate is a lipid-soluble form of vitamin B1 (thiamine). S-Benzoylthiamine O-monophosphate facilitates the action of thiamine diphosphate, a cofactor for the enzyme transketolase. The activation of transketolase enzyme accelerates the precursors of advanced glycation end products (AGEs) towards the pentose phosphate pathway thereby reducing the production of AGEs. The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes. The anti-AGE property of S-Benzoylthiamine O-monophosphate certainly makes it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. S-Benzoylthiamine O-monophosphate appears to have a also cardioprotective role in potentiating angiogenesis and inhibiting apoptosis in diabetic complications. S-Benzoylthiamine O-monophosphate also modulates pathways such as arachidonic acid (AA), nuclear transcription Factor kappaB (NF-kappaB), protein kinase B, mitogen-activated protein kinases (MAPK) and vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathways, which are also responsible for it's anti-inflammatory and anti-tumor properties. S-Benzoylthiamine O-monophosphate has been shown to be a dual inhibitory action on COX-2 and LOX-5, supressing PKC and NF-kappaB activation, preventing the downregulation of PKB/Akt during diabetic complications and enhancing cell survival, regulating GSK-3 activity through Akt (rendering it's anti-AD activity) and inducing cell death through paraptosis.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

466.45

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)